FANCA anticorps (AA 1272-1439)

N° du produit ABIN7599897

L’anticorps Lapin Polyclonal anti-FANCA a été validé pour WB, ELISA et FACS. Il convient pour détecter FANCA dans des échantillons de Rat et Souris.

Aperçu rapide pour FANCA anticorps (AA 1272-1439) (ABIN7599897)

Antigène: FANCA (Fanconi Anemia Group A Protein (FANCA))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCA est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-FANCA anticorps

Épitope: AA 1272-1439

Fonction: Anti-Fanca/FAA Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Fanca/FAA Antibody Picoband® (ABIN7599897). Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Fanca/FAA recombinant protein (Position: E1272-F1439).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Abu-Issa, R., Eichele, G., Youssoufian, H. Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood 94: 818-824, 1999. 2. Bouchlaka, C., Abdelhak, S., Amouri, A., Ben Abid, H., Hadiji, S., Frikha, M., Ben Othman, T., Amri, F., Ayadi, H., Hachicha, M., Rebai, A., Saad, A., Dellagi, K., Tunisian Fanconi Anemia Study Group. Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations. J. Hum. Genet. 48: 352-361, 2003. 3. Castella, M., Pujol, R., Callen, E., Trujillo, J. P., Casado, J. A., Gille, H., Lach, F. P., Auerbach, A. D., Schindler, D., Benitez, J., Porto, B., Ferro, T., and 20 others. Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations. Blood 117: 3759-3769, 2011.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur FANCA

Antigène: FANCA (Fanconi Anemia Group A Protein (FANCA))

Autre désignation: Fanca

Sujet:

Synonyms: DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46, MCM5, CDC46

Tissue Specificity: Ubiquitous.

Background: Fanconi anaemia, complementation group A, also known as FAA, FACA and FANCA, is a protein which in humans is encoded by the FANCA gene. Acts upstream of or within several processes, including gonad development, regulation of CD40 signaling pathway, and regulation of regulatory T cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including gut, liver, lung, reproductive system, and spleen. Used to study Fanconi anemia complementation group A. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple), acute myeloid leukemia, esophagus squamous cell carcinoma, ovarian disease (multiple), and skin melanoma. Orthologous to human FANCA (FA complementation group A).

Poids moléculaire: 180 kDa

ID gène: 14087

Pathways: Réparation de l'ADN